| Enantioselective Total Synthesis of the （＋） Antipode of Zeylenone |
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| 作者姓名： | AnLIU ZhanZhuLIU ZhongMeiZOU ShiZhiCHEN LiZhenXU ShiLinYANG |
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| 作者单位： | [1]InstituteofMedicinalPlantDevelopment,ChineseAcademyofMedicalSciencesandPekingUnionMedicalCollege,Beijing100094 [2]InstituteofMateriaMedica,ChineseAcademyofMedicalSciencesandPekingUnionMedicalCollege,Beijing100050 |
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| 摘 要： | Starting from shikimic acid, the total synthesis of zeylenone was studied. The product was proved to be the ( )antipode of zeylenone through analysis and comparison of their respective spectra (including NMR, MS, IR and CD) and optical data. The absolute configuration of the natural product was thus determined to be (1 S,2S,3R).
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| 关 键 词： | 合成 Zeylenone 对映体 莽草酸 光谱分析 核磁共振 质谱分析 |
Enantioselective Total Synthesis of the (+) Antipode of Zeylenone |
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| AnLIU ZhanZhuLIU ZhongMeiZOU ShiZhiCHEN LiZhenXU ShiLinYANG.Enantioselective Total Synthesis of the (+) Antipode of Zeylenone[J].Chinese Chemical Letters,2004,15(12):1433-1436. |
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| Authors: | An LIU Zhan Zhu LIU Zhong Mei ZOU Shi Zhi CHEN Li Zhen XU Shi Lin YANG Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical College Beijing Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Bejing |
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| Institution: | An LIU,Zhan Zhu LIU,Zhong Mei ZOU,Shi Zhi CHEN,Li Zhen XU,Shi Lin YANG Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100094 Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Bejing 100050 |
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| Abstract: | Starting from shikimic acid, the total synthesis of zeylenone was studied. The product
was proved to be the (+)antipode of zeylenone through analysis and comparison of their respective
spectra (including NMR, MS, IR and CD) and optical data. The absolute configuration of the
natural product was thus determined to be (1S,2S,3R). |
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| Keywords: | Zeylenone absolute configurtion shikimic acid total synthesis enantiomer |
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