New strategy for the synthesis of N-aryl pyrroles: Cu-catalyzed C-N cross-coupling reaction of trans-4-hydroxy-l-proline with aryl halides期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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*New strategy for the synthesis of N-aryl pyrroles: Cu-catalyzed C-N cross-coupling reaction of trans-4-hydroxy-l-proline with aryl halides*

Authors:	V Prakash ReddyA Vijay Kumar K Rama Rao

Institution:	Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 500 607, India

Abstract:	trans-4-Hydroxy-l-proline is used for the first time as an effective nucleophilic coupling partner with aryl halides mediated by copper iodide with Cs₂CO₃ as the base and DMSO as the solvent. Utilizing this protocol cross-coupling of trans-4-hydroxy-l-proline with a wide variety of substituted aryl halides to produce N-aryl pyrroles in moderate to good yields.

Keywords:	Aryl halides l-proline" target="_blank">trans-4-Hydroxy-l-proline N-Aryl pyrroles Cross-coupling Copper iodide
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