Caged molecular beacons: controlling nucleic acid hybridization with light |
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| Authors: | Wang Chunming Zhu Zhi Song Yanling Lin Hui Yang Chaoyong James Tan Weihong |
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| Affiliation: | State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China. |
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| Abstract: | We have constructed a novel class of light-activatable caged molecular beacons (cMBs) that are caged by locking two stems with a photo-labile biomolecular interaction or covalent bond. With the cMBs, the nucleic acid hybridization process can be easily controlled with light, which offers the possibility for a high spatiotemporal resolution study of intracellular mRNAs. |
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