Gold-catalysed synthesis of amino acid-derived 2,5-disubstituted oxazoles |
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| Authors: | Paradise Christopher L Sarkar Pooja R Razzak Mina De Brabander Jef K |
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| Institution: | Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323, Harry Hines Blvd., Dallas, Texas 75390, USA. |
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| Abstract: | Amino acid-derived propargylic amides are cyclised in a one-pot, Au(III)-catalysed operation to yield 5-bromomethyl oxazoles. These compounds are further elaborated to bis-heterocycles, dipeptide mimics and more. |
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