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Application of CR-39 for alpha-autoradiography and in vivo detection of B accumulations in tumor bearing mice |
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| Authors: | K Ogura H Yanagie M Eriguchi T Matsumoto H Kobayashi |
| Institution: | a Physical Science Laboratories, College of Industrial Technology, Nihon University, 1-2-1 Izumi-cho, Narashino, Chiba 275, Japan b Department of Surgery, Institute of Medical Science, University of Tokyo, 4-6-1 Shiroganedai, Minato-ku, Tokyo 108, Japan c Metabolism and Pharmacokinetics group, Omiya Research Laboratory, Nikken Chemicals Co. Ltd., 1-346 Kitabukuro-cho, Omiya, Saitama 33, Japan d Institute for Atomic Energy, Rikkyo University, 2-5-1 Nagasaka, Yokosuka, Kanagawa, 240-01, Japan |
| Abstract: | It is required to achieve an accurate measurement of 10B distributions and concentrations in the tumor cells for boron neutron capture therapy (BNCT). We employed a technique of neutron capture autoradiography (NCAR) of the whole body samples of tumor bearing mice using CR-39 plastic track detectors to the measurements of 10B accumulations in mice. In order to confirm the validity of the NCAR measurements, the differential REL spectrum for the neutron-induced particles emitted from the standard filter paper sheets was compared with that for 10B-compound solution. Differential REL spectrum for protons originated from the biogenically abundant nuclides through 14N (n, p)14C and 1H (n, n′) 1H reactions was measured in vivo using a small piece of CR-39 inserted into the tumor of mouse. |
| Keywords: | Boron neutron capture therapy alpha-autoradiography CR-39 10B-compound solution tumor bearing mouse LET spectrum measurements in vivo |
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