Effect of pH, temperature and solvent mole ratio on solubility of disodium 5′-guanylate in water + ethanol system |
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| Authors: | Rui ZhangJian Ma Jun LiYanbin Jiang Mingying Zheng |
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| Institution: | a School of Chemistry and Chemical Engineering, South China University of Technology, 381, Wushan Road, Guangzhou, Guangdong 510640, China
b Star Lake Bioscience Co., Inc., Zhaoqing 526040, China |
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| Abstract: | Solubility of disodium 5′-guanylate in water + ethanol binary solvent mixtures was determined by a gravimetric method in the temperature range from 283.15 K to 323.15 K, pH range from 8 to 10 and at different water/ethanol mole ratios. The effects of pH, temperature and water/ethanol mole ratio on the solubility were investigated in detail. The modified Apelblat model and the combined nearly ideal binary solvent (CNIBS)/Redlich-Kister model were selected to correlate the experimental data. The results showed that the experimental data was satisfactorily correlated by the (CNIBS)/Redlich-Kister model, but for the modified Apelblat model, the correlation was not so satisfactory in some cases. |
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| Keywords: | Disodium 5&prime -guanylate Solubility Measurement Correlation |
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