Diffusion coefficients in ethanol and in water at 298 K: Linear free energy relationships期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Diffusion coefficients in ethanol and in water at 298 K: Linear free energy relationships

Authors:	Elizabeth E. HillsAuthor Vitae Michael H. AbrahamAuthor VitaeAnne HerseyAuthor Vitae Chris D. BevanAuthor Vitae

Affiliation:	^a Department of Chemistry, University College London, 20 Gordon Street, London WC1H OAJ, UK ^b GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK

Abstract:

Keywords:	k, rate constant for absorption BCS, Biopharmaceutics Classification Scheme D₁₂, the diffusion coefficient of solute 1 in solvent 2 V_W, Van der Waals volumes av log P_oct, an average of log P_oct values (calculated with C log P) PSA, the polar surface area (Å ²) E, the solute excess molar refractivity in units of (cm³ mol^&minus 1)/10 S, the solute dipolarity/polarizability A, overall or summation hydrogen bond acidity B, overall or summation hydrogen bond basicity V, the McGowan volume in units of (cm³ mol^&minus 1)/100 SP, solute property log k (ARK), absorption rate constants in humans HIA, human intestinal absorption
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