Carbocyclic 4′-epi-formycin |
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Authors: | Jian Zhou |
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Institution: | Department of Chemistry and Biochemistry, College of Sciences and Mathematics, Auburn University, Auburn, AL 36849-5312, United States |
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Abstract: | Formycin is a naturally occurring biologically responsive C-nucleoside. In pursuing the design and syntheses of novel C-nucleosides, convenient access to carbocyclic C-nucleosides based on the formycin framework was a goal. One such target was carbocyclic 4′-epi-formycin (4). This compound is reported via a procedure based on an asymmetric aldol/ring closure metathesis strategy. To provide a preliminary glimpse into the biological characterization of 4 an antiviral assay was conducted. Target 4 was found to be inactive and to lack cytotoxicity to the host cells. |
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Keywords: | Cyclopentyl C-nucleoside Pyrazolo[4 3-d]pyrimidine Diastereomeric aldol |
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