| Influence of Monomer Types on the Designability of a Protein—Model Chain |
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| 作者姓名： | 梁好均 王元元 |
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| 作者单位： | [1]TheOpenLaboratoryforBond－SelectiveChemistry,DepartmentofPolymerScienceandEngineering,UniversityofScienceandTechnologyofChina,Hefei230026 [2]TheOpenLaboratoryforBond－SelectiveChemistry,DepartmentofPolymer |
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| 摘 要： | In a three-dimensional off-lattice model,the method of Shakhnovich and Gutin for minimizing the Hamiltonian is applied to the design of a protein-model chain.The effect of the number of hydrophobic and hydrophilic monomer types on the designability of a protein-model chain is investigated.The simulation results reveal that the number of hydrophobic monomer types is a much more important factor than that of the polar monomer types in the design of a protein-model chain.
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| 关 键 词： | 分子生物学 蛋白质模型链 可设计性 |
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