| PEG-400介质中L-脯氨酸催化香豆素-3-羧酸乙酯的合成 |
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| 引用本文： | 曾鸿耀,卢小冬,徐婷,孙国峰.PEG-400介质中L-脯氨酸催化香豆素-3-羧酸乙酯的合成[J].化学研究与应用,2012,24(5):745-749. |
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| 作者姓名： | 曾鸿耀 卢小冬 徐婷 孙国峰 |
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| 作者单位： | 乐山师范学院化学与生命科学学院,四川乐山,614000 |
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| 基金项目： | 乐山师范学院2011年度大学生创新性实验项目资助 |
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| 摘 要： | 用PEG-400为溶剂,L-脯氨酸作为催化剂,能高效简便地催化水杨醛与丙二酸二乙酯通过Knoevenagel缩合反应得到香豆素3-羧酸乙酯.本方法具有易于操作,后处理方便,反应时间较短,反应收率较高,催化剂和溶剂价廉易得,而且环境友好等优点.
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| 关 键 词： | 香豆素 Knoevenagel缩合 L-脯氨酸 绿色合成 PEG-400 |
Synthesis of ethyl coumarin-3-carboxylate catalyzed by L-proline in PEG-400 |
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| ZENG Hong-yao
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LU Xiao-dong
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XU Ting
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SUN Guo-feng.Synthesis of ethyl coumarin-3-carboxylate catalyzed by L-proline in PEG-400[J].Chemical Research and Application,2012,24(5):745-749. |
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| Authors: | ZENG Hong-yao LU Xiao-dong XU Ting SUN Guo-feng |
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| Institution: | (College of Chemistry and Biology Science,Leshan Normal University,Leshan 614000,China) |
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| Abstract: | L-proline could effectively catalyze the synthesis of ethyl coumarin-3-carboxylate from aldehydes and diethyl malonate using PEG-400 as the solvent.This method had the advantages such as easy to operate,convenient work-up,short reaction time,high reaction yield,cheap catalyst and solvent,and environmentally benign procedure. |
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| Keywords: | coumarin knoevenagel condensation L-proline green synthesis PEG-400 |
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