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| 克拉霉素与百里酚蓝荷移配合物的光度分析研究 | |
| 引用本文： | 李俊,李焱,王国庆,武娜,李全民.克拉霉素与百里酚蓝荷移配合物的光度分析研究[J].化学研究与应用,2012,24(4):565-568. |
| 作者姓名： | 李俊 李焱 王国庆 武娜 李全民 |
| 作者单位： | 1. 河南焦作师范高等专科学校,河南焦作,454000 2. 郑州轻工业学院材料与化学工程学院,河南郑州,450002 3. 河南师范大学化学与环境科学学院,河南新乡,453007 |
| 基金项目： | 国家自然科技基金，河南省科技厅基础与前沿项目，河南省教育厅自然科学研究计划项目 |
| 摘 要： | 利用克拉霉素与百里酚蓝在乙醇介质发生荷移反应,建立了荷移分光光度法测定克拉霉素含量的方法.结果表明,荷移反应生成1∶1型配合物,最大吸收波长为442 nm,表观摩尔吸光系数为ε=1.66×104L·mol-1·cm-1,克拉霉素测定线性范围为8.278～57.59 mg/L. |
| 关 键 词： | 克拉霉素 百里酚蓝 荷移反应 分光光度法 |
Spectrophotometric determination of clarithromycin by charge-transfer reaction between clarithromycin and thymol blue |
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| LI Jun , LI Yan , WANG Guo-qing , WU Na , LI Quan-min.Spectrophotometric determination of clarithromycin by charge-transfer reaction between clarithromycin and thymol blue[J].Chemical Research and Application,2012,24(4):565-568. | |
| Authors: | LI Jun LI Yan WANG Guo-qing WU Na LI Quan-min |
| Institution: | 1.Henan Jiaozuo Teacher,s College,Jiaozuo 454000,China;2.School of Material and Chemical Engineering,Zhengzhou University of Light Industry,Zhengzhou 45002,China;3.College of Chemistry and Environmental Science,Henan Normal University,Xinxiang 453007,China) |
| Abstract: | Base on the charge-transfer reaction between clarithromycin and thymol blue in ethanol solution,a spectrophotometric method was established for the determination of clarithromycin in preparations.The experimental results show that the composition ratio of the complex is 1 ∶ 1,the apparent molar absorptivity is 1.66 × 10 4 L.mol-1.cm-1 at maximum absorption wavelength 442nm,and the linear range of the determination is 8.278-57.59mg / L. |
| Keywords: | clarithromycin thymol blue charge transfer reaction spectrophotometry |
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