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| 氯代苯二酚双苯醚的合成与抑菌活性研究 | |
| 引用本文： | 辛莹,王玉良,杨志荣,侯若彤,罗娟. 氯代苯二酚双苯醚的合成与抑菌活性研究[J]. 化学研究与应用, 2012, 24(7): 1117-1120 |
| 作者姓名： | 辛莹 王玉良 杨志荣 侯若彤 罗娟 |
| 作者单位： | 1. 四川大学化学学院,四川成都610064;成都医学院药学院,四川成都610083 2. 四川大学化学学院,四川成都,610064 3. 四川大学生命科学学院,四川成都,610064 |
| 摘 要： | 为了寻求优良的苯醚类新化合物抑菌剂,本文设计合成了邻(对)苯二酚二-(2-氯-4-羟基苯基)醚,其结构均经1HNMR、IR、MS和元素分析证实,并且测试了化合物对大肠杆菌,金黄色葡萄球菌,白色念珠菌,白色葡萄球菌,变形杆菌,卡他双球菌,青枯假单胞菌的抑菌活性,初步研究结果表明:羟基的位置对活性存在较大影响,羟基的个数对试剂的抑菌活性没有明显的影响。 |
| 关 键 词： | 氯代苯二酚双苯醚 抑菌活性 合成 |
Synthesis and antimicrobial activity of chloronated benzenediol diphenyl ethers |
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| XIN Ying , WANG Yu-liang , YANG Zhi-Rong , HOU Ruo-tong , LUO Juan. Synthesis and antimicrobial activity of chloronated benzenediol diphenyl ethers[J]. Chemical Research and Application, 2012, 24(7): 1117-1120 | |
| Authors: | XIN Ying WANG Yu-liang YANG Zhi-Rong HOU Ruo-tong LUO Juan |
| Affiliation: | 1*(1.College of Chemistry,Sichuan University,Chengdu 610064,China; 2.Pharmaecutical College Of Chengdu Medical College,Chengdu 610083,China; 3.Faculty of Life Science,Sichuan University,Chengdu 610064,China) |
| Abstract: | In order to seek novel phenyl ether compounds as excellent antibacterial agent,o(p)benzenediol-di(2-chloro-4-hydroxy phenyl)ethers were synthesized,their structures were characterized by 1HNMR,IR,Ms spectra and elemental analysis.Their antimicrobial activities on Escherichia coli(E.coli),Staphylococcus aureaus(S.aureus),Candida albicans(c.albicans),Staphylococcus albus(s.albus),Proteus vulgaris(p.vulgaris),Diplococcus catarrhalis(D.cata),Pseudomona ssolanacearum(p.solanacearum)were investigated.The preliminary results showed that the position of hydroxyl group had greater effect,but the number of hydroxyl groups had no obvious effect on their antimicrobial activities. |
| Keywords: | chloronated benzenediol diphenyl ethers antimicrobial activity synthesis |
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