| 野黄芩素的合成与表征 |
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| 引用本文： | 王晶,刘湘,董保平,吕新,许伟超. 野黄芩素的合成与表征[J]. 化学研究与应用, 2012, 24(3): 480-483 |
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| 作者姓名： | 王晶 刘湘 董保平 吕新 许伟超 |
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| 作者单位： | 江南大学化学与材料工程学院,江苏无锡,214122 |
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| 基金项目： | 国家重点实验室专项经费项目 |
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| 摘 要： | 本文以3,4,5-三甲氧基苯酚与对甲氧基肉桂酰氯为原料,在三氟化硼-乙醚络合物催化下,发生Friedel–Crafts反应,生成9-羟基-5,6,7,4’–四甲氧基查尔酮;然后9-羟基-5,6,7,4’–四甲氧基查尔酮在碘的二甲基亚砜溶液中发生分子内环合得到5,6,7,4’-四甲氧基黄酮;最后在酸性条件下,5,6,7,4’-四甲氧基黄酮发生去甲基化水解反应制得野黄芩素,总产率达到54%。化合物结构经IR,1H NMR和MS表征。该方法简单易行,具有广泛的应用前景。
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| 关 键 词： | 野黄芩素 3,4,5-三甲氧基苯酚 查尔酮 合成 |
Synthesis and characterization of scutellarein |
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| WANG Jing , LIU Xiang , DONG Bao-ping , LV Xin , XU Wei-chao. Synthesis and characterization of scutellarein[J]. Chemical Research and Application, 2012, 24(3): 480-483 |
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| Authors: | WANG Jing LIU Xiang DONG Bao-ping LV Xin XU Wei-chao |
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| Affiliation: | (School of Chemical and Material Engineering,Jiangnan University,Wuxi 214122,China) |
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| Abstract: | In this paper,3,4,5-trimethoxyphenol was directly acylated with p-methoxycinnamoyl chloride to give corresponding chalcone in the presence of BF3-Et2O complex by Friedel-Crafts reaction.Under the action of I2/DMSO,5,6,7,4′-tetramethoxylflavone was obtained by intramolecular cyclization of chalcone.Finally,the demethylation of 5,6,7,4′-tetramethoxylflavone was performed to give the desired scutellarein in the overall yield of 54%.The structures of all compounds were confirmed by IR,1H NMR and MS.The method was concise,efficient and had a wide range of applications. |
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| Keywords: | scutellarein 3,4,5-trimethoxyphenol chalcone synthesis |
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