| 大茴香醛改性海藻酸钠凝胶的制备及释药性能 |
| |
| 引用本文： | 吴敏,倪才华. 大茴香醛改性海藻酸钠凝胶的制备及释药性能[J]. 化学研究与应用, 2012, 24(3): 400-403 |
| |
| 作者姓名： | 吴敏 倪才华 |
| |
| 作者单位： | 江南大学化学与材料工程学院,江苏无锡,214122 |
| |
| 摘 要： | 在酸催化下使海藻酸钠与对甲氧基苯甲醛(又名大茴香醛)发生缩醛化反应,使其疏水改性,并将其制备成凝胶。利用红外(FTIR)、荧光、透射电镜(TEM)、扫描电镜(SEM)、紫外、热重分析(TGA)对产物进行了表征。结果表明,大茴香醛成功地与海藻酸钠发生了反应。该凝胶可以作为药物载体对牛血清白蛋白进行包埋释放,结果发现,改性后的产物其载药率和缓释性能比未改性的海藻酸钠有了一定的提高。
|
| 关 键 词： | 海藻酸钠 缩醛化 凝胶 药物释放 |
Preparation of alginate gel modified by anise aldehyde and controlled release |
| |
| WU Min , NI Cai-hua. Preparation of alginate gel modified by anise aldehyde and controlled release[J]. Chemical Research and Application, 2012, 24(3): 400-403 |
| |
| Authors: | WU Min NI Cai-hua |
| |
| Affiliation: | (School of Chemical and Material Engineering,Jiangnan university,Wuxi,China) |
| |
| Abstract: | Hydrophobically modified alginate were obtained through acetalization of alginate with p-methoxy benzaldehyde catalysted by an acid.The modified alginate was characterized by FTIR spectra,fluorescence,transmission electronic microscopy,scanning electronic microscopy,UV spectrum,thermal analysis.The modified alginate hydrogel was used as a drug carrier for encapsulation and release of bovine serum albumin.The results showed that drug loading ability and slow release were observed. |
| |
| Keywords: | alginate acetalization hydrogel drug release |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
