| 生物激活磁共振成像造影剂的研究进展 |
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| 引用本文： | 俞开潮,吕志勇,姚遥,付世涛,丁尚武,周锦兰. 生物激活磁共振成像造影剂的研究进展[J]. 波谱学杂志, 2010, 27(3): 355-368. DOI: 10.3969/j.issn.1000-4556.2010.03.007 |
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| 作者姓名： | 俞开潮 吕志勇 姚遥 付世涛 丁尚武 周锦兰 |
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| 作者单位： | 1.华中科技大学 化学与化工学院, 湖北 武汉 430074；2.中山大学 化学系，台湾 高雄 80424 |
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| 基金项目： | 国家自然科学基金资助项目，台湾国科会"大学追求卓越计划"资助项目 |
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| 摘 要： | 介绍了磁共振成像新一代造影剂--生物激活造影剂（亦称之为“酶激活”、“生物应答”或“智能型”造影剂）的研究进展.主要讲述了这类造影剂的设计原理、性能与作用. 它们主要分别对生物体内的酶、金属离子浓度、pH等敏感.
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| 关 键 词： | 磁共振成像 造影剂 生物敏感 |
| 收稿时间： | 2010-07-20 |
Recent Progress in Development of Bio-Active MRI Contrast Agents |
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| YU Kai-chao,LV Zhi-yong,YAO Yao,FU Shi-tao,DING Shang-wu,ZHOU Jin-lan. Recent Progress in Development of Bio-Active MRI Contrast Agents[J]. Chinese Journal of Magnetic Resonance, 2010, 27(3): 355-368. DOI: 10.3969/j.issn.1000-4556.2010.03.007 |
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| Authors: | YU Kai-chao LV Zhi-yong YAO Yao FU Shi-tao DING Shang-wu ZHOU Jin-lan |
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| Affiliation: | 1. School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074; ;2. Department of Chemistry, National Sun Yat-Sen University, Kaohsiung 80424 |
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| Abstract: | Bio-activated MRI contrast agents are often called “enzyme activated”, “bio-responsive” or “smart” contrast agents because they respond, specifically, to enzymatic activity, metal ion concentration, pH et al factors, respectively. Recent progress in the development of bio activated MRI contrast agents is reviewed with the emphasis on the design principle of contrast generation based on the analysis of the structure, properties and functions of these compounds. |
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| Keywords: | magnetic resonance imaging (MRI) contrast agents bio-responsive |
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