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Separation and identification of the Z and E isomers of 2-(3-pentenyl)pyridine by capillary electrophoresis and nuclear magnetic resonance spectroscopy |
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| Authors: | Andrew G McKillop Roger M Smith Raymond C Rowe Stephen A C Wren |
| Institution: | a Department of Chemistry, Loughborough University of Technology, Loughborough, Leics. LE11 3TU, UK b Zeneca Pharmaceuticals, Hurdsfield Industrial Estate, Macclesfield, Cheshire, SK10 2NA, UK |
| Abstract: | A mixture of the Z and E isomers of 2-(3-pentenyl)pyridine has been separated with baseline resolution by capillary electrophoresis. Using molecular modelling it was proposed that the smaller more rapidly migrating peak would be the Z isomer. This agreed with a 38:62 (Z/E) composition by nuclear magnetic resonance spectroscopy. The sample was also investigated by gas chromatography coupled to mass spectrometry. |
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