New automatized method with amperometric detection for the determination of azithromycin |
| |
Authors: | Miriam E Palomeque Patricia I Ortíz |
| |
Institution: | a Departamento de Química, Universidad Nacional del Sur, Bahía Blanca, Buenos Aires, Argentina b INFIQC, Departamento de Físico Química, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina |
| |
Abstract: | A FIA-amperometric method for azithromycin determination was developed. A working glassy carbon electrode and a Ag/AgCl/NaCl (3 M) reference electrode were used. The determination is based on the electrochemical oxidation of the azithromycin at 0.9 V in Britton-Robinson buffer solution (pH 8.0). Due to the adsorption of the reaction products on the electrode surface, an effective cleaner cycle was implemented. By using the optimum chemical and FIA conditions, a concentration linear range of 1.0-10.0 mg L−1 and a detection limit (LOD) of 0.76 mg L−1 are obtained. The method was validated and satisfactorily applied to the determination of azithromycin in pharmaceutical formulations. |
| |
Keywords: | FIA Amperometry Azithromycin Pharmaceutical preparations |
本文献已被 ScienceDirect 等数据库收录! |
|