Determination of gas-phase produced ethyl parathion and toluene 2,4-diisocyanate by ion mobility spectrometry, gas chromatography and liquid chromatography

Ethyl parathion and toluene 2,4-diisocyanate (2,4-TDI) vapors were generated using a vapor generation system that was designed for the evaporation of liquid samples at known flow rates. The vapor generation of parathion and 2,4-TDI posed a challenge because of their low volatility and tendency to absorb into surfaces of the vapor generation system. Experimental concentration of parathion was determined using gas chromatography-mass spectrometry (GC-MS). 2,4-TDI was derivatized with 1-(2-pyridyl)piperazine to urea derivative which concentration was analyzed using high performance liquid chromatography (HPLC). In addition, in combination with vapor generator, aspiration IMS was used for monitoring ion mobility cell (IMCell) and semiconductor cell (SCCell) responses to parathion and 2,4-TDI vapors. The chromatographic results correlated well with the IMCell response data, showing high specificity of IMS to parathion and 2,4-TDI. The concentrations of parathion and 2,4-TDI at the detection limit of IMS were significantly lower than IDLH threshold values of parathion or 2,4-TDI, demonstrating high sensitivity of IMS to both compounds. The IMS patterns of both chemicals and the influence of humidity on IMCell and SCCell sensitivity were analyzed.