Flow injection-chemiluminescence determination of sulfadiazine in compound naristillae |
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| Authors: | Haiyan Liu Yuhong Hao Yuzhi Fang |
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| Affiliation: | a School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China
b Department of Chemistry, East China Normal University, Shanghai 200062, China |
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| Abstract: | A simple, sensitive and selective flow injection-chemiluminescence method for the determination of sulfadiazine in compound naristillae has been investigated. It is based upon the chemilimunescence reaction of sulfadiazine, formaldehyde and potassium permanganate in polyphosphate acid medium. The optimum conditions for the chemiluminescence emission were investigated. Under the optimum conditions, the linear range for the determination of sulfadiazine was 8.0 × 10−7 to 2.0 × 10−4 mol/L with a detection limit of 2.0 × 10−7 mol/L calculated as proposed by IUPAC and a relative standard deviation of 2.53% for 11 solutions of 5.0 × 10−5 mol/L sulfadiazine on the same day. It was also found that the coexisting ephedrine hydrochloride did not interfere with this determination. This led to the successful application of the proposed method for the direct and selective determination of sulfadiazine in compound naristillae. |
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| Keywords: | Flow injection Chemiluminescence Permanganate Compound pharmaceutical Sulfadiazine |
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