Synthesis, Crystal Structure and Biological Activity of a Planar Copper Complex Derived from S-benzyldithiocarbazate |
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| Authors: | QIU Xiao-Yang ZHU Mei-An LIU Ying DING Xiu-Yun ZHANG Ping |
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| Affiliation: | [1]Department of Chemistry, Shangqiu Normal University, Shangqiu 476000, China [2]Department of Chemistry, Fuyang Normal University, Fuyang 236000, China |
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| Abstract: | A planar transition metal complex Cu(L)2(L =(E)-benzyl-2-(4-nitrobenzylidene)-hydrazinecarbodithioate)has been prepared and determined by X-ray single-crystal diffraction.The crystal belongs to the monoclinic system,space group P21/c with a = 6.7101(11),b = 16.952(3),cmm-1,F(000)= 742,S= 1.021,R= 0.0634 and wR= 0.1077 for 813 observed reflections with I2σ(I)and 205 parameters.In the molecular structure of the title complex,the copper atom exhibits a slightly distorted square-planar geometry in which the basal plane is defined by two N and two S atoms from two bidentate ligands.The complex was evaluated for its antitumor activity against two kinds of cell lines(MKN45 and HepG2)by MTT method.The preliminary bioassay indicates that the complex exhibits weak antitumor activity. |
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| Keywords: | copper(Ⅱ)complex Schiff base crystal structure biological activity |
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