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N-Substituted tetrahydro-1,3-oxazines and oxazolidines. 1. A new version of the Mannich reaction involving amino alcohols
Authors:Korepin  A G  Galkin  P V  Glushakova  N M  Lagodzinskaya  G V  Loginova  M V  Lodygina  V P  Eremenko  L T
Institution:(1) Institute of Problems of Chemical Physics, Russian Academy of Sciences, 18 Institutskii prosp., 142432 Chernogolovka, Moscow Region, Russian Federation
Abstract:A new version of the Mannich reaction involving amino alcohols (3-aminopropan-1-ol and aminoethanol) was developed. These compounds react with formaldehyde and CH or NH acids to give N-substituted tetrahydro-1,3-oxazines or oxazolidines.
Keywords:C-  N- and O-aminomethylation  amino alcohols  tetrahydro-1  3-oxazines and oxazolidines  amides  imides  nitrogen heterocycles  1  1-dinitroalkanes
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