| 马兜铃酸与人血清白蛋白相互作用的荧光光谱研究 |
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| 引用本文： | 刘家琴,田建袅,谢建平,边清泉,胡之德. 马兜铃酸与人血清白蛋白相互作用的荧光光谱研究[J]. 光谱实验室, 2006, 23(1): 123-126 |
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| 作者姓名： | 刘家琴 田建袅 谢建平 边清泉 胡之德 |
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| 作者单位： | 绵阳师范学院化学系,四川省,绵阳市,621000;兰州大学,兰州市,730000;广西师范大学,广西,桂林市,541001;周口师范学院,河南省,周口市,466000;绵阳师范学院化学系,四川省,绵阳市,621000;兰州大学,兰州市,730000 |
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| 基金项目： | 四川省教育厅资助项目 , 绵阳师范学院校科研和教改项目 |
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| 摘 要： | 采用荧光光谱技术研究了模拟生理条件下马兜铃酸与人血清白蛋白(HSA)的相互作用.结果显示:马兜铃酸与人血清白蛋白有强的结合,结合位置与色氨酸残基间的距离r为2.5nm,二者间的结合是疏水和静电力共同作用的结果.
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| 关 键 词： | 马兜铃酸 人血清白蛋白 相互作用 |
| 文章编号： | 1004-8138(2006)01-0123-04 |
| 收稿时间： | 2005-09-02 |
| 修稿时间： | 2005-09-20 |
Study on the Interaction between Aristolochic Acid and Human Serum Albumin by Spectrofluorimetry |
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| LIU Jia-Qin,TIAN Jian-Niao,XIE Jian-Ping,BIAN Qing-Quan,HU Zhi-De. Study on the Interaction between Aristolochic Acid and Human Serum Albumin by Spectrofluorimetry[J]. Chinese Journal of Spectroscopy Laboratory, 2006, 23(1): 123-126 |
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| Authors: | LIU Jia-Qin TIAN Jian-Niao XIE Jian-Ping BIAN Qing-Quan HU Zhi-De |
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| Affiliation: | Department of Chemistry, Mianyang Teachers College,Mianyang,Sichuan 621000, P. R. China;Lanzhou University,Lanzhou 730000,P. R, China; Guanxi Normal University , Guilin o Guanxi 541001 , P. R. China ;Zhoukou Teachers College,Zhoukou,Henan 466000,P. R. China |
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| Abstract: | The interaction between aristolochic acid and bovine serum albumin (HSA) under physiological conditions was investigated by fluorescence quenching methods. There is a strong interaction between aristolochic acid and HAS at 2. 5nm distance from the tryptophan residue. Hvdrophobic and electrostatic forces play main roles in the binding of aristolochic acid to HSA according to experiment results. |
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| Keywords: | Aristolochic Acid HSA Interaction. |
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