| 原卟啉（PP）、血卟啉（HP）和双卟啉醚、酯混合物（DHE）对蛋白质主链结构的光敏损伤特征─—兼论它们在Hala细胞死亡中的作用 |
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| 引用本文： | 许以明,张志义,杨勇正.原卟啉（PP）、血卟啉（HP）和双卟啉醚、酯混合物（DHE）对蛋白质主链结构的光敏损伤特征─—兼论它们在Hala细胞死亡中的作用[J].光散射学报,1995(Z1). |
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| 作者姓名： | 许以明 张志义 杨勇正 |
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| 作者单位： | 中国科学院生物物理研究所 |
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| 摘 要： | 原卟啉（ＰＰ）、血卟啉（ＨＰ）和双卟啉醚、酯混合物（ＤＨＥ）对蛋白质主链结构的光敏损伤特征─—兼论它们在Ｈａｌａ细胞死亡中的作用许以明，张志义，杨勇正（中国科学院生物物理研究所北京１００１０１）ＣｈａｒａｃｔｃｆｏｆＰｈｏｔｏｓｅｎｓｉｔｉｖｅＤａｍ...
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Charactcf of Photosensitive Damage of PP，HP and DHE to The Structure of Main-Chain of Protein |
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| Abstract: | Abstract Laser Raman spectroscopy was used to investigate the microcosmic and photosensitive damage of active componets PP， HP and DHE of porphyrin’s drug to the structure of the main-chain of protein （lysozyme ）.The results indecated that the damages of the three active componete to the structure of lysozyme are considerably different ： The damages of PP toβ-sheet andβ-turn of the structure of the main-chain were stronger than the damages of HP and DHE to that and the resuIt was found in a dose－independent way，It is suggested that the damages to protein mainly dependent on the structure of PP，HP and DHE. |
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