| DNA与水溶性C60衍生物的相互作用 |
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| 引用本文： | 方鹏飞,赵元弟,庞代文,陈远荫.DNA与水溶性C60衍生物的相互作用[J].北京大学学报(自然科学版),2001,37(2):153-156. |
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| 作者姓名： | 方鹏飞 赵元弟 庞代文 陈远荫 |
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| 作者单位： | 武汉大学化学与环境学院，武汉，430072 |
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| 摘 要： | 发展了一种新的研究方法，即DNA修饰金电极表面电化学方法，结合紫外光谱研究了一种水溶性C60衍生物——C60乙醇胺加成物与ds DNA的相互作用。结果表明，富勒烯衍生物是以DNA双螺旋的大沟为作用靶点的。
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| 关 键 词： | 富勒烯 表面修饰电化学方法 DNA 相互作用 |
| 收稿时间： | 2000-07-13 |
Study of Interaction of Water-Soluble Fullerene Derivatives with DNA |
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| FANG Pengfei,ZHAO Yuandi,PANG Daiwen,CHEN Yuanyin.Study of Interaction of Water-Soluble Fullerene Derivatives with DNA[J].Acta Scientiarum Naturalium Universitatis Pekinensis,2001,37(2):153-156. |
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| Authors: | FANG Pengfei ZHAO Yuandi PANG Daiwen CHEN Yuanyin |
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| Institution: | Department of Chemistry, Wuhan University, Wuhan, 430072 |
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| Abstract: | The interaction of ds DNA with a water\|soluble C\-\{60\} derivative was studied using surface electrochemistry of DNA modified electrode and UV\|Vis spectroscopy.It was found that the absorbed band of C\-\{60\} shifted positively in company with the hypochromic effect.Co(phen) 3 2+ was used as indicator to study the interaction.The results show that this kind of C\-\{60\} derivative can interact strongly with ds DNA,the bind site is the major groove of helix. |
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| Keywords: | fullerene surface electrochemical methods DNA interaction |
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