| 芬太尼类物质卡芬太尼的定性检验方法研究 |
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| 引用本文： | 钱振华,陈月猛,花镇东.芬太尼类物质卡芬太尼的定性检验方法研究[J].分析试验室,2019,38(3):270-274. |
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| 作者姓名： | 钱振华 陈月猛 花镇东 |
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| 作者单位： | 公安部物证鉴定中心,北京,100038;贵州省贵阳市公安局禁毒支队,贵阳,550018;公安部禁毒情报技术中心,北京,100193 |
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| 基金项目： | 中央级公益性科研院所基本科研业务费专项 |
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| 摘 要： | 报道中国首次缴获的芬太尼类物质卡芬太尼,建立其气相色谱-质谱(GC-MS)、超高效液相色谱-四极杆-飞行时间质谱(UPLC-Q-TOF MS)和红外光谱(FTIR)定性检验方法。未知样品用甲醇和水提取,取上清液,采用GC-MS和UPLC-Q-TOF MS进行分析;样品粉末置于衰减全反射(ATR)附件中,进行FTIR采集。GC-MS检测,保留时间为13. 05 min的未知组分的质谱碎片主要特征离子峰有m/z 303,105,243,187,96,154。UPLC-Q-TOF MS检测,保留时间为3. 976 min的未知组分的准分子离子峰为m/z 395. 2325,碰撞诱导解离(CID)模式下二级质谱主要离子有m/z 335. 2117,279. 1856,246. 1490,146. 0966,134. 0966,113. 0599。FTIR检测,在1724,1635,1593,1352,1225,704 cm-1等处出现吸收峰。经NIST谱库检索、已报道文献中信息比对及对其高分辨质谱数据的解析,鉴定为卡芬太尼。该方法可以用于实际案件的检测。
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| 关 键 词： | 芬太尼类 卡芬太尼 气相色谱质谱联用(GC-MS) 超高效液相色谱-串联四极杆飞行时间质谱(UPLC-Q-TOF MS) 红外光谱(FTIR) |
Identification of a fentanyl analogue-carfentanil in seized material by GC-MS,UPLC-Q-TOF MS and FTIR |
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| QIAN Zhen-hua,CHEN Yue-meng,HUA Zhen-dong.Identification of a fentanyl analogue-carfentanil in seized material by GC-MS,UPLC-Q-TOF MS and FTIR[J].Chinese Journal of Analysis Laboratory,2019,38(3):270-274. |
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| Authors: | QIAN Zhen-hua CHEN Yue-meng HUA Zhen-dong |
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| Institution: | (Institute of Forensic Science Ministryof Public Security, Beijing 100038;Drug Control Unit of Guiyang Public Security Bureau ofGuizhou Province, Guiyang 550018;Drug Intelligence and Forensic Technology Center, Ministry of Public Security, Beijing 100193) |
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| Abstract: | QIAN Zhen-hua;CHEN Yue-meng;HUA Zhen-dong(Institute of Forensic Science Ministryof Public Security, Beijing 100038;Drug Control Unit of Guiyang Public Security Bureau ofGuizhou Province, Guiyang 550018;Drug Intelligence and Forensic Technology Center, Ministry of Public Security, Beijing 100193) |
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| Keywords: | Fentanyl analogue Carfentanil Gas chromatography-mass spectrometry ( GC-MS) Ultra performance liquid chromatography-quadrupole time-of-flight-mass spectrometry ( UPLC-Q-TOF MS) Fourier transform infrared spectroscopy ( FTIR) |
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