Two Novel Quassinoid Glycosides with Antiviral Activity from the Samara of Ailanthus altissima |
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| Authors: | Qing-Wei Tan Jian-Cheng Ni Jian-Ting Shi Jian-Xuan Zhu Qi-Jian Chen |
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| Institution: | 1.Key Laboratory of Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou 350002, China; (J.-T.S.); (J.-X.Z.);2.The Engineering Technology Research Center of Characteristic Medicinal Plants of Fujian, Ningde Normal University, Ningde 352100, China; |
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| Abstract: | Phytochemistry investigations on Ailanthus altissima (Mill.) Swingle, a Simaroubaceae plant that is recognized as a traditional herbal medicine, have afforded various natural products, among which C20 quassinoid is the most attractive for their significant and diverse pharmacological and biological activities. Our continuous study has led to the isolation of two novel quassinoid glycosides, named chuglycosides J and K, together with fourteen known lignans from the samara of A. altissima. The new structures were elucidated based on comprehensive spectra data analysis. All of the compounds were evaluated for their anti-tobacco mosaic virus activity, among which chuglycosides J and K exhibited inhibitory effects against the virus multiplication with half maximal inhibitory concentration (IC50) values of 56.21 ± 1.86 and 137.74 ± 3.57 μM, respectively. |
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| Keywords: | Ailanthus altissima (Mill ) Swingle Simaroubaceae quassinoid lignanoid tobacco mosaic virus |
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