Transition‐Metal‐Catalyzed Cyanation by Using an Electrophilic Cyanating Agent,N‐Cyano‐N‐phenyl‐p‐toluenesulfonamide (NCTS) |
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Authors: | Jie Cui Jian Song Dr Qing Liu Prof Hui Liu Prof Yunhui Dong |
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Institution: | School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo, P.?R. China |
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Abstract: | The ability to introduce a nitrile group into a biologically active compound is very useful in organic synthesis, owing to the importance of nitrile groups in transformations and tuning molecular properties. To date, nucleophilic cyanation has been the most used strategy for this purpose, whilst electrophilic cyanation reactions are less developed. Recently, the electrophilic cyanation reagent N‐cyano‐N‐phenyl‐p‐toluenesulfonamide (NCTS) has received increasing attention, owing to its superior properties in terms of safety and practicality. This Focus Review summarizes recent progress in transition‐metal‐catalyzed cyanation reactions that use NCTS. |
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Keywords: | cross-coupling cyanides homogeneous catalysis synthetic methods transition metals |
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