Rhenium(I)‐Catalyzed ortho‐C−H Addition to Bicyclic Alkenes |
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| Authors: | Dr. Sekar Prakash Yu‐Che Chang Prof. Chien‐Hong Cheng |
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| Affiliation: | 1. Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan;2. http://mx.nthu.edu.tw/%7Echcheng 0000-0002-2483-7353 Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan |
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| Abstract: | Hydroarylation of bicyclic alkenes has been developed using a low‐valent ReI‐catalyzed, directing group‐assisted C?H bond activation strategy. The addition of sodium acetate significantly improves the reaction efficiency; moreover, bicyclic alkenes such as 7‐oxa and aza benzonorbornadienes worked efficiently under this reaction condition. Preliminary mechanistic studies suggest that, after the alkene insertion, the rhenacycle preferentially undergoes protonolysis rather than reductive elimination. |
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| Keywords: | bicyclic alkene C− H activation exo-selectivity hydroarylation rhenium catalyst |
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