Cobalt‐Catalyzed C−H Nitration of Indoles by Employing a Removable Directing Group |
| |
| Authors: | Paridhi Saxena Dr. Manmohan Kapur |
| |
| Affiliation: | Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Academic Building II, Bhauri, Bhopal, MP, India |
| |
| Abstract: | A mild and efficient C(sp2)?H nitration of 3‐substituted indoles, by using the economical and non‐toxic cobalt nitrate hexahydrate [Co(NO3)2 ? 6 H2O] as a catalyst and tert‐butyl nitrite (TBN) as the nitro source, is reported. This approach provides a unique methodology involving a site‐selective C?N bond formation for preparation of C‐2 substituted nitro indoles. Utilization of the tBoc as the removable directing group enhances the synthetic utility of the method. |
| |
| Keywords: | cobalt catalysis C(sp2)− H nitration indoles removable directing group weak coordinating groups |
|
|
