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Enantioselective Alkylation of N‐Arylhydrazones Derived from α‐Keto Esters and Isatin Derivatives through Asymmetric Phase‐Transfer Catalysis |
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| Authors: | Dr Qi‐Kai Kang Dr Sermadurai Selvakumar Prof?Dr Natarajan Arumugam Prof?Dr Abdulrahman I Almansour Prof?Dr Raju Suresh Kumar Prof?Dr Keiji Maruoka |
| Institution: | 1. Laboratory of Synthetic Organic Chemistry and Special Laboratory of Organocatalytic Chemistry, Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto, Japan;2. Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia;3. School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, China |
| Abstract: | The phase‐transfer‐catalyzed asymmetric alkylation reactions of N‐arylhydrazones derived from α‐keto‐esters and isatin derivatives afford enantioenriched azo compounds that bear a tetra‐substituted carbon stereocenter in good yields with high chemo‐ and enantioselectivity. The alkylation products can be readily converted into chiral amino esters, hydrazine derivatives, and aza‐β‐lactams without loss of enantiopurity. |
| Keywords: | alkylation isatin N-arylhydrazone phase-transfer catalyst α -keto ester |