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Radical Cation Salt‐initiated Aerobic C−H Phosphorylation of N‐Benzylanilines: Synthesis of α‐Aminophosphonates |
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| Authors: | Prof. Xiaodong Jia Xiaofei Liu Prof. Yu Yuan Pengfei Li Wentao Hou Kaixuan He |
| Affiliation: | 1. School of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu, China;2. College of Chemistry&Chemical Engineering, Northwest Normal University, Lanzhou, Gansu, China |
| Abstract: | A radical cation salt‐initiated phosphorylation of N‐benzylanilines was realized through an aerobic oxidation of the sp3 C?H bond, providing a series of α‐aminophosphonates in high yields. An investigation of the reaction scope revealed that this mild catalyst system is superior in good functional group tolerance and high reaction efficiency. The mechanistic study implied that the cleavage of the sp3 C?H bond was involved in the rate‐determining step. |
| Keywords: | α -aminophosphonate benzylanilines phosphorylation radical cation salt synthetic methods |