Preparative isolation of (+)-beta-eudesmol fromAmyris balsamifera |
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Authors: | T. A. van Beek R. Kleis G. P. Lelyveld AE. de Groot |
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Affiliation: | (1) Department of Organic Chemistry, Phytochemical Section, Agricultural University, Dreijenplein 8, NL-6703 HB Wageningen, The Netherlands |
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Abstract: | Summary Optically pure (+)-beta-eudesmol is a possible starting material for the synthesis of several termite defense compounds. A two step procedure for the isolation of gram quantities of (+)-beta-eudesmol from commercially availableAmyris balsamifera oil (syn. West Indian sandalwood oil), containing 8% beta-eudesmol, was developed. Step one consisted of an efficient vacuum distillation of the total oil. Step two was a medium pressure LC separation with an AgNO3 impregnated silica gel stationary phase. Several other separation procedures failed due to the presence of many closely related sesquiterpene alcohols (75% of the oil). |
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Keywords: | Column liquid chromatography Preparative isolation (+)-Beta-eudesmol Amyris balsamifera |
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