Synthesis of the ABC ring system of Azaspiracid. 2. A systematic study into the effect of C(16) and C(17) substitution on bis-spirocyclization |
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Authors: | Carter Rich G Graves David E Gronemeyer Melissa A Tschumper Gregory S |
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Institution: | Department of Chemistry and Biochemistry, University of Mississippi, University, Mississippi 38677, USA. rich.carter@oregonstate.edu |
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Abstract: | reaction: see text] A systematic study into the effect of C(16) and C(17) substitution on the stereochemical outcome of bis-spirocyclization to form the ABC ring system of azaspiracid is disclosed. Successful construction of the natural 10R,13R bis-spirocyclic stereochemistry has been accomplished on the C(16) benzyloxy-containing precursor. |
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