Total synthesis of pyridovericin: studies toward the biomimetic synthesis of pyridomacrolidin |
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| Authors: | Baldwin Jack E Adlington Robert M Conte Aurelia Irlapati Nageswara Rao Marquez Rodolfo Pritchard Gareth J |
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| Affiliation: | Dyson Perrins Laboratory, Oxford University, South Parks Road, Oxford OX1 3QY, UK. jack.baldwin@chem.ox.ac.uk |
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| Abstract: | [reaction: see text] The total synthesis of the novel metabolite pyridovericin 1 is reported. The synthesis of this key intermediate in our proposed biomimetic synthesis of pyridomacrolidin 2 has been accomplished in good yield from readily available 2,4-dihydroxypyridine. |
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