| 1-SUBSTITUTED PHENYL-β-CARBOLINES:SYNTHESIS AND SPECIFIC BINDING WITH BENZODIAZEPINE RECEPTOR |
| |
| 引用本文： | Zi Li XIAO,Ren WEN,An Gou MO,Xi Peng JING,Feng Yan SUN. 1-SUBSTITUTED PHENYL-β-CARBOLINES:SYNTHESIS AND SPECIFIC BINDING WITH BENZODIAZEPINE RECEPTOR[J]. 中国化学快报, 1991, 2(9): 677-680 |
| |
| 作者姓名： | Zi Li XIAO Ren WEN An Gou MO Xi Peng JING Feng Yan SUN |
| |
| 作者单位： | a Dept of Medicinal Chemistry Shanghai Medical University(SMU);b Lab of Isotope SMU;c Dept of Neurobiology SMU Shanghai 200032 |
| |
| 摘 要： | By the condensation of tryptamine with appropriate substituted benzalde-hyde followed by Pictet-Spengler reaction,a series of 1-aryl-tetrahydro-β-carbo-lines(THβCs)were obtained.After dehydrogenation using sulfur,Pd-C or lead te-traacetate(LTA),these THβCs can give the corresponding β-carbolines(βCs)whichexhibit specific binding with rat brain benzodiazepine receptor in vitro.
|
1-SUBSTITUTED PHENYL-β-CARBOLINES:SYNTHESIS AND SPECIFIC BINDING WITH BENZODIAZEPINE RECEPTOR |
| |
| Zi Li XIAO,Ren WEN,An Gou MO,Xi Peng JING,Feng Yan SUN. 1-SUBSTITUTED PHENYL-β-CARBOLINES:SYNTHESIS AND SPECIFIC BINDING WITH BENZODIAZEPINE RECEPTOR[J]. Chinese Chemical Letters, 1991, 2(9): 677-680 |
| |
| Authors: | Zi Li XIAO Ren WEN An Gou MO Xi Peng JING Feng Yan SUN |
| |
| Affiliation: | a Dept of Medicinal Chemistry Shanghai Medical University(SMU);b Lab of Isotope SMU;c Dept of Neurobiology SMU Shanghai 200032 |
| |
| Abstract: | By the condensation of tryptamine with appropriate substituted benzaldehyde followed by Pictet-Spengler reaction, a series of 1-aryl-tetrahydro-β-carbo-lines(THβCs)were obtained.After dehydrogenation using sulfur, Pd-C or lead tetraacetate(LTA), these THβCs can give the corresponding β-carbolines(βCs)which exhibit specific binding with rat brain benzodiazepine receptor in vitro. |
| |
| Keywords: | |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《中国化学快报》浏览原始摘要信息 |
|
点击此处可从《中国化学快报》下载全文 |
