Photokilling Squamous Carcinoma Cells SCCVII with Ultrafine Particles of Selected Metal Oxides |
| |
Authors: | Ivanković Siniša Gotić Marijan Jurin Mislav Musić Svetozar |
| |
Affiliation: | Sinia Ivankovi, Marijan Goti, Mislav Jurin and Svetozar Musi |
| |
Abstract: | The ability of ultrafine particles of TiO2, WO3 and iron-doped TiO2 to kill cancer cells in the presence of UV irradiation was investigated. The best photokilling effect on carcinoma cells SCVII cultured in vitro showed iron-doped TiO2 ultrafine particles synthesized by the sol-gel procedure with starting chemicals Ti(IV)-isopropoxide and anhydrous Fe(II)-acetate. It was found that a small particle size and high dispersity influenced citotoxicity and photocatalytic efficiency. The remarkable photokiling effect of highly iron-doped TiO2 ultrafine particles (the molar ratio Fe/Ti = 0.136) in the presence of UV irradiation was observed. The influence of ultrafine metal oxide particles on the inhibition of cancer cell proliferation was measured using a 3H-thymidine incorporation test. The possible mechanism involved in the photokilling of carcinoma cells with ultrafine particles of selected metal oxides was discussed. |
| |
Keywords: | TiO2 WO3 iron-doped TiO2 ultrafine particles cancer cells photokilling effect |
本文献已被 SpringerLink 等数据库收录! |