| 类Mannich反应合成2,5-二苯基-3,3-二取代-2,3-二氢-1,4,2-氧氮磷杂环戊烯-2-氧化物 |
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| 引用本文： | 陈茹玉,冯克胜.类Mannich反应合成2,5-二苯基-3,3-二取代-2,3-二氢-1,4,2-氧氮磷杂环戊烯-2-氧化物[J].高等学校化学学报,1991,12(12):1605. |
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| 作者姓名： | 陈茹玉 冯克胜 |
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| 作者单位： | 南开大学元素有机化学研究所, 天津, 300071 |
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| 摘 要： | 本文报道了以苯甲酰胺,醛(或酮)苯基二氯化膦为原料进行的Mannich反应,其产物经部分水解合成了α-(N-苯甲酰氨基)二取代甲基苯基膦酸(Ⅰ),此化合物脱水关环得2,5-二苯基-3,3-二取代-2,3-二氢-1,4,2-氧氮磷杂环戊烯-2-氧化物(Ⅱ).经1HNMR及元素分析证明了Ⅰ和Ⅱ的结构,并对反应机理进行了探讨。
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| 关 键 词： | Mannich反应 合成 机理 |
| 收稿时间： | 1990-10-12 |
Syntheses of 2,5-Diphenyl-3,3-disubstituted-2,3-dihydro-1,4,2- oxazaphosphole-2-oxides by Mannich Reaction |
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| Chen Ru-yu,Feng Ke-sheng.Syntheses of 2,5-Diphenyl-3,3-disubstituted-2,3-dihydro-1,4,2- oxazaphosphole-2-oxides by Mannich Reaction[J].Chemical Research In Chinese Universities,1991,12(12):1605. |
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| Authors: | Chen Ru-yu Feng Ke-sheng |
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| Institution: | Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071 |
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| Abstract: | By using Mannich reaction with benzamide, aldehydes (or ketones) and phenyldi-chlorophosphine as the starting materials and with the product being partially hydrolysed, α-(N-benzoyl) aminoalkyl phenylphosphinic acids (Ⅰ) were synthesized. The products (Ⅰ) were cy-clized to 2, 5-diphenyl-3, 3-disubstituted-2, 3-dihydro-1, 4. 2-oxazaphosphole-2-oxides (Ⅱ) by dehydrating with SOCl2and Et3N. The structures of Ⅰ and Ⅲ are confirmed by 1H NMR and elementary analysis. The mechanism of the Mannich reaction is also discussed. |
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| Keywords: | Mannich reaction Synthesis Mechanism |
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