Wedelolides A and B: novel sesquiterpene delta-lactones, (9R)-eudesman-9,12-olides, from Wedelia trilobata |
| |
Authors: | That Quang Ton Jossang Jean Jossang Akino Kim Phi Phung Nguyen Jaureguiberry Ginette |
| |
Institution: | Laboratoire de Chimie et Biochimie des Substances Naturelles, UMR 5154 Centre National de la Recherche Scientifique, USM 502, Muséum National d'Histoire Naturelle, 63 rue Buffon, 75005 Paris, France. |
| |
Abstract: | Two new sesquiterpene lactones, wedelolides A (1) and B (2), were isolated by bioassay-guided fractionation from the leaves of Wedelia trilobata, together with known trilobolides 6-O-isobutyrate (3) and 6-O-methacrylate (4). The compounds 1 and 2 were the first examples of an unprecedented framework: a novel sesquiterpene delta-lactone, (9R)-eudesman-9,12-olide. The structures of the antimalarial wedelolides A (1) and B (2) were determined on the basis of MS and 2D NMR spectral analysis. The absolute configuration of eight carbon stereocenters of compounds 1 and 2 was determined to be 1S,4S,5S,6R,7S,8S,9R,10S by mean of auxiliary chiral MTPA derivatives. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|