Practical, scalable, high-throughput approaches to eta3-pyranyl and eta3-pyridinyl organometallic enantiomeric scaffolds using the Achmatowicz reaction |
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Authors: | Coombs Thomas C Lee Maurice D Wong Heilam Armstrong Matthew Cheng Bo Chen Wenyong Moretto Alessandro F Liebeskind Lanny S |
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Institution: | Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, USA. |
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Abstract: | A unified strategy for the high-throughput synthesis of multigram quantities of the eta(3)-oxopyranyl- and eta(3)-oxopyridinylmolybdenum complexes TpMo(CO)(2)(eta(3)-oxopyranyl) and TpMo(CO)(2)(eta(3)-oxopyridinyl) is described (Tp = hydridotrispyrazolylborato). The strategy uses the oxa- and aza-Achmatowicz reaction for the preparation of these organometallic enantiomeric scaffolds, in both racemic and high enantiopurity versions. |
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