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Synthesis and Neuroprotective Properties of Isosteric Analogs of Nicotine |
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| Authors: | E. D. Matveeva T. A. Podrugina I. G. Morozkin S. E. Tkachenko N. S. Zefirov |
| Affiliation: | (1) M. V. Lomonosov State University, Moscow, 119899, Russia;(2) Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, 142432 Moscow region, Russia |
| Abstract: | A method has been developed for the synthesis of isosteric analogs of nicotine involving ethers of S(-)-1-2-pyrrolidinemethanol and S(-)-1-2-pyrrolidineethanol based on the Mitsunobu reaction. The results of testing the synthesized compounds as calcium channel blockers are presented. |
| Keywords: | prolinol and homoprolinol ethers neuroprotectors calcium channel blockers Mitsunobu reaction |
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