Highly enantioselective catalytic carbon dioxide incorporation reaction: nickel-catalyzed asymmetric carboxylative cyclization of bis-1,3-dienes |
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Authors: | Takimoto Masanori Nakamura Yoichi Kimura Kaoru Mori Miwako |
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Affiliation: | Graduate School of Pharmaceutical Sciences, Hokkaido University, Hokkaido, Sapporo 060-0812, Japan. |
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Abstract: | A method for nickel-catalyzed asymmetric carbon dioxide (CO2) incorporation via carbon-carbon bond formation was developed. In the presence of a catalytic amount of Ni(acac)2 and MeO-MOP, various bis-1,3-dienes reacted with CO2 (1 atm) and a diorganozinc reagent (Me2Zn or Ph2Zn) to afford cyclic carboxylic acids in good yields (71-100%) and with high enantioselectivities (90-96% ee). |
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