Synthesis of a caged glutamate for efficient one- and two-photon photorelease on living cells |
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| Authors: | Fedoryak Olesya D Sul Jai-Yoon Haydon Philip G Ellis-Davies Graham C R |
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| Institution: | Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA 19102, USA. |
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| Abstract: | We have synthesized a biologically inert, photosensitive derivative of the major excitatory amino acid, L-glutamate (which we call MDNI-glu) that makes more efficient use of incident light than all other caged glutamates. Laser flash photolysis of MDNI-glu in acutely isolated hippocampal brain slices evoked a rapid increase in intracellular Ca2+ concentration in astrocytes. |
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