Use of asymmetric propargyl dicobalt hexacarbonyl complexes in organic synthesis: Access to enantiomerically pure α-hydroxy acid derivatives |
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Authors: | Juan M Betancort Carmen Ma Rodríguez Víctor S Martín |
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Institution: | Juan M. Betancort, Carmen Ma Rodríguez,Víctor S. Martín* |
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Abstract: | The trapping under different conditions of the carbocation generated by acid treatment of chiral Co2(CO)6-complexed propargylic secondary alcohols permitted access to either diastereoisomer at the propargylic center. Further chemical manipulations provided either enantiomer of enantiomerically pure 1,2-difunctionalized molecules such as 1,2-diols, α-hydroxy-aldehydes or α-hydroxy-acids. |
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Keywords: | Nicholas reaction asymmetric synthesis |
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