(1) Research Technology & Proteins Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, 46285, U.S.A;(2) Endocrine Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, 46285, U.S.A
Abstract:
A library of potential agonists and antagonists for adrenergic receptors was prepared using high-throughput solution-phase
parallel synthesis. Traditional solution-phase reductive amination reactions followed by rapid purification by ion exchange
chromatography yielded products with near-analytical purity. An array of ketones and amines, arranged in an 8 × 12 matrix,
were combined to form 96 individual compounds.
This revised version was published online in August 2006 with corrections to the Cover Date.