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The use of high-throughput synthesis and purification in the preparation of a directed library of adrenergic agents |
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| Authors: | Siegel Miles G Shuker Athony J Droste Christine A Hahn Patrick J Jesudason Cynthia D McDonald III John H Matthews Donald P Rito Christopher J Thorpe Andrew J |
| Institution: | (1) Research Technology & Proteins Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, 46285, U.S.A;(2) Endocrine Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, 46285, U.S.A |
| Abstract: | A library of potential agonists and antagonists for adrenergic receptors was prepared using high-throughput solution-phase parallel synthesis. Traditional solution-phase reductive amination reactions followed by rapid purification by ion exchange chromatography yielded products with near-analytical purity. An array of ketones and amines, arranged in an 8 × 12 matrix, were combined to form 96 individual compounds. This revised version was published online in August 2006 with corrections to the Cover Date. |
| Keywords: | adrenergic agonists and antagonists ethanolamine library ion exchange chromatography parallel synthesis reductive amination |
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