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Occurrence of spontaneous resolution of ketoprofen with a racemic crystal structure by simple crystallization under nonequilibrium preferential enrichment conditions
Authors:Gonnade Rajesh G  Iwama Sekai  Sugiwake Ryusuke  Manoj Kochunnoonny  Takahashi Hiroki  Tsue Hirohito  Tamura Rui
Affiliation:Graduate School of Human and Environmental Studies, Kyoto University, Kyoto 606-8501, Japan.
Abstract:Nearly racemic ketoprofen, which satisfies the requirements for the occurrence of preferential enrichment, was spontaneously resolved into the two enantiomers by simple crystallization under nonequilibrium conditions using high concentrations.
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