Occurrence of spontaneous resolution of ketoprofen with a racemic crystal structure by simple crystallization under nonequilibrium preferential enrichment conditions |
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Authors: | Gonnade Rajesh G Iwama Sekai Sugiwake Ryusuke Manoj Kochunnoonny Takahashi Hiroki Tsue Hirohito Tamura Rui |
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Affiliation: | Graduate School of Human and Environmental Studies, Kyoto University, Kyoto 606-8501, Japan. |
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Abstract: | Nearly racemic ketoprofen, which satisfies the requirements for the occurrence of preferential enrichment, was spontaneously resolved into the two enantiomers by simple crystallization under nonequilibrium conditions using high concentrations. |
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