Copper-mediated cyanation of aryl halide with the combined cyanide source |
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| Authors: | Zhang Guoying Ren Xinyi Chen Jianbin Hu Maolin Cheng Jiang |
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| Institution: | College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou 325027, PR China. |
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| Abstract: | A simple copper-mediated cyanation of aryl halide with the combination of ammonium bicarbonate and N,N-dimethylformamide as a cyanide source is achieved, providing nitriles in moderate to good yields. This new approach represents an exceedingly practical and safe method for the synthesis of aryl nitriles. |
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