Improving the yield of mono-DNA-functionalized gold nanoparticles through dual steric hindrance |
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| Authors: | Li Zhengtao Cheng Enjun Huang Wenxiao Zhang Tao Yang Zhongqiang Liu Dongsheng Tang Zhiyong |
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| Institution: | Key Laboratory of Standardization and Measurement for Nanotechnology, National Center for Nanoscience and Technology, No. 11 Zhongguancun Beiyitiao, Beijing 100190, PR China. |
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| Abstract: | A novel strategy of dual steric hindrance, which was obtained by Janus modification of gold nanoparticles (Au NPs) and volume exclusion of DNA, was adopted to prepare mono-DNA-modified Au NPs. The yield of mono-DNA-functionalized Au NPs significantly improved from 44 to 70% in the reaction between Au NPs and thiolated DNA. Furthermore, the specificity of mono-DNA-functionalized Au NPs was enhanced from 57 to 95%. The as-prepared Au NPs without postsynthetic treatment showed good controllability in self-assembly fabrication of complex nanostructures. |
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