LC and Non-Aqueous CE Determination of Phenothiazines in Autopsy Samples |
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| Authors: | K. Madej M. Kala M. Woźniakiewicz |
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| Affiliation: | 1. Faculty of Chemistry, Department of Analytical Chemistry, Jagiellonian University, Ingardena St. 3, 30-060, Kraków, Poland
2. Institute of Forensic Research, Westerplatte St. 9, Kraków, Poland
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| Abstract: | Comparative determinations of various phenothiazine derivatives in blood and urine samples were carried out using HPLC in reversed-phase mode and non-aqueous capillary electrophoresis (NACE). The examined samples of biological fluids originated from six forensic cases concerning poisonings with drugs, including the following commonly used phenothiazines: chlorpromazine, levomepromazine, promazine, and perazine. The quantification limits for both methods were similar and ranged from 0.02 to 0.35 µg mL?1. The correlation coefficient (r2) between the results obtained by two methods was 0.9869. |
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