Polymer-supported triazenes as smart reagents for the alkylation of carboxylic acids |
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Authors: | Erb Bernhard Kucma Jean-Philippe Mourey Sandrine Struber Fritz |
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Affiliation: | Novartis Pharma, Chemical & Analytical Development, 4002 Basel, Switzerland. |
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Abstract: | Starting from polystyrene, a simple four-step synthesis of polymer-supported alkyltriazenes (alkyl=Me, Et, benzyl) is described. With this synthesis, a loading capacity of 2.2 mmol g(-1) can be reached. The most prominent application of these polymer-supported reagents is the rapid, highly selective and high-yielding esterification of carboxylic acids, which involves a simple "mix and filter off" procedure at room temperature. If stored in a refrigerator, these reagents are stable for many months and they can be recycled several times. |
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Keywords: | alkylation combinatorial chemistry diazo compounds polymers solid‐phase synthesis |
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