幽门螺杆菌感染小鼠模型的应用进展

幽门螺杆菌动物模型是幽门螺杆菌感染导致人类胃炎、消化性溃疡、胃癌等致病机制研究的基础, 也是幽门螺杆菌感染和胃肠外疾病相关性研究的重要工具. 近年来幽门螺杆菌感染动物模型得到了广泛的应用和发展, 制备感染模型常用的动物有小鼠、蒙古沙鼠、豚鼠、悉生乳猪和恒河猴等, 其中幽门螺杆菌悉尼菌株感染的小鼠模型使用最广泛. 本文对幽门螺杆菌感染小鼠模型应用的最新进展做一综述.

Progress in application of mouse models of Helicobacter pylori infection

Animal models of Helicobacter pylori are the basis for the study of pathogenic mechanisms of Helicobacter pylori infection in humans such as gastritis, peptic ulcer, and gastric cancer. They are also important tools for studying the correlation between Helicobacter pylori infection and extra gastric diseases. In recent years, animal models of Helicobacter pylori infection have been widely used and developed. The commonly used animals for infection models include mice, Mongolian gerbils, guinea pigs, gnotobiotic piglets and rhesus monkeys. Mice infected with Helicobacter pylori Sydney Strain are the most widely used models among them. In this article, the latest progress in the application of mouse models is reviewed.